In situ monitoring of single molecule binding reactions with time-lapse atomic force microscopy on functionalized DNA origami.
نویسندگان
چکیده
Individual biomolecular binding events were recorded in situ by combining time-lapse atomic force microscopy and DNA origami. Single streptavidin molecules bound to specifically biotinyated DNA origami were simply counted as a function of time to obtain a direct measure of the binding rate.
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ورودعنوان ژورنال:
- Nanoscale
دوره 3 6 شماره
صفحات -
تاریخ انتشار 2011